International Journal of Research and Review

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Original Research Article

Year: 2017 | Month: July | Volume: 4 | Issue: 7 | Pages: 35-39

Correlation between Serum Cystatin C and Creatinine in Apparently Healthy Subjects

Pallavi Mahajan

Demonstrator, Department of Biochemistry, Government Medical College, Jammu, J&K, India.


Glomerular filtration rate is typically the best indicator for the assessment of kidney function in both healthy and diseased patients. The various methods are used for the estimation of GFR like exogenous substances such as inulin, iohexol, 51 Cr EDTA or 125 I-labeled iothalamate, 24 hours creatinine clearance, 99mTc-DTPA renography. But the inulin clearance is considered as the gold standard for the evaluation of the GFR. These techniques are time-consuming, labor-intensive, expensive, and require administration of substances that make them incompatible with routine monitoring. Serum cystatin C is another marker of renal function that has been proposed as potentially superior to serum creatinine level for estimating renal function, because it is thought to be produced at a constant rate by most nucleated cells. In the present study, the serum cystatin C and serum creatinine levels were estimated in apparently healthy subjects and eGFR-cystatin C and eGFR-creatinine was calculated. It was observed that serum cystatin C shows significant correlation with serum creatinine and negative correlation with eGFR-cystatin C and eGFR-creatinine. Hence, with the help of simple assay and appropriate measures, the kidney disease can be prevented at the early stages.

Key words: Glomerular filtration rate, cystatin C, creatinine, renal disease.

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