Original Research Article
Year: 2017 | Month: July | Volume: 4 | Issue: 7 | Pages: 15-23
Syndrome X, C - Reactive Protein and Proteinuria in Newly Diagnosed Patients of Type 2 Diabetes Mellitus: A Cross-Sectional Study
Sangeeta Singh1*, Basant Joshi2*, Seema Gupta3*, Ashok Kumar4**
1Associate Professor, 2Tutor, 3Assistant Professor, 4Associate Professor,
*Department of Biochemistry, **Department of Medicine,
Government Medical College, Haldwani, Uttarakhand, India
Corresponding Author: Sangeeta Singh
Introduction: Diabetes Mellitus (DM) is the commonest metabolic abnormality in the world. Type 2 diabetes, the commonest form of diabetes constitutes nearly 90% of diabetic population in any country. The Syndrome X consists of a constellation of metabolic abnormalities that confer increased risk of cardiovascular disease and diabetes mellitus. Inflammation, as assessed by C-reactive protein (CRP) may be an important precursor of the syndrome X and type 2 diabetes. Syndrome X is a known risk factor for proteinuria in the general population.
Materials and Methods: 100 patients of newly diagnosed type 2 diabetes mellitus in the age group of 25-60 years were included in the study. Patients with Gestational diabetes mellitus were excluded from the study.
Results: Of the 100 patients studied, 58 patients has syndrome X according to the International Diabetes Federation (IDF) criteria. Among the studied subjects 33 males had increased WHR>0.90(Normal <0.90), whereas all the females had WHR>0.85 (Normal <0.85). Mean waist circumference in males with MS was 96.26±1.01as compared to those without syndrome X(85.6±50.57) and mean waist circumference in females with MS was (90.3±40.68) as compared to those without syndrome X(75.63±0.25). Mean serum hs-CRP levels in patients with syndrome X was (6.35±1.07) as compared to those without syndrome X(7.09±1.30). Mean Proteinuria levels in patients with metabolic syndrome was (549.34±68.80) as compared to those without syndrome X (456.74±33.04). The mean Proteinuria level was markedly raised in patients of metabolic syndrome as compared to those without syndrome X. This difference was found to be markedly significant (p < 0.01).
Conclusion: In conclusion, considering that Syndrome X is a modifiable risk factor, early detection of syndrome X would be a cost-effective strategy to decrease the prevalence of proteinuria and chronic kidney disease in the general population.
Key words: Diabetes Mellitus, Syndrome X, C - Reactive Protein and Proteinuria[PDF Full Text]