Original Research Article
Year: 2017 | Month: July | Volume: 4 | Issue: 7 | Pages: 95-99
Evaluation and Correlation of Serum Zinc with Oxidative Stress and Insulin Resistance
Mr. P. Krushna Kishore1, Dr. Ipsita Chodhary2, Dr. Pallavi Anand2, Dr. U.N Singh3
1Research Scholar, 2Associate Professor, 3Professor & HOD,
Dept of Biochemistry, Rama Medical College, Kanpur, UP
Corresponding Author: Mr. P. Krushna Kishore
Background: Zinc is an important mineral in regulating glucose homeostasis and oxidative stress Zn dyshomeostasis is often associated with pathogenesis of T2DM and its complications.
Objective: to Evaluate the serum zinc levels and to find the possible correlation between serum zinc and oxidative stress, Insulin resistance in healthy and T2DM patients.
Materials and methods: The present study was carried out in the Department of Biochemistry on 360 subjects patient in the age group of 35-70 years, attended OP in Rama Medical college & Hospital. Among them 180 healthy subjects enrolled as control group remaining 180 T2DM patients were served as case group. Serum zinc and Serum Insulin were measured .Insulin resistance was calculated from HOMA-IR method.MDA levels were measured in order to asses oxidative stress.
Results: The concentration of serum Zn levels were significantly (p<0.0001) lower in cases (82.70 ±14.13) as compared to the controls (93.90 ±12.24). There was negative correlation found between serum Zn levels and Insulin resistance, MDA levels in cases of type 2 DM.
Conclusions: There is an association exits between serum Zn and Oxidative stress and there is an inverse correlation found between Serum Zn and Insulin resistance in T2DM patients.
Key words: Serum Zinc, HOMA-IR, Oxidative stress, T2DM[PDF Full Text]