Original Research Article
Year: 2017 | Month: June | Volume: 4 | Issue: 6 | Pages: 72-77
Role of Mean Platelet Volume in Dengue Fever - A Prognostic Marker
Manoharan A1, Pammy Sinha2
1Assistant Professor, 2Professor and Head,
Dept. of Pathology, Sri Lakshmi Narayana Institute of Medical Sciences, Pondicherry.
Corresponding Author: Pammy Sinha
Introduction: Dengue Fever (DF) has a virus infective etiology caused by an arbovirus. This virus is spread by Aedes mosquitoes. These results in two complications such as Dengue Haemorrhagic Fever (DHF) and in its severe form Dengue Shock Syndrome (DSS) which can threaten the patient's life mainly through high vascular permeability and shock. Due to the rise in the spread of arboviral infection, medical care services are persistently struggling to improve patient management and appropriate steps going on to control vector transmission. The transfusion of platelets is indicated for the thrombocytopenic patients both as prophylaxis as well as treatment of haemorrhage. Platelet count and MPV are strongly associated with prognosis in critically ill patients. Mean platelet volume (MPV) is considered as a valuable marker in predicting the inflammatory process and disease activity. Even after the transfusion of platelets, few patients do not show the appropriate increase in platelet count.
Aims and objectives: 1. To assess the role of mean platelet volume in dengue fever.
2. To determine the incidence of dengue fever in various age groups.
Materials and methods: Platelet count and Mean platelet volume (MPV) are calculated using automated haematology analyzer.
Results: Out of 68 serologically diagnosed dengue cases, the maximum percentage of patients were in the age group of 20 to 40 years ( 47.05%) followed by 60 years and above (20.58%) with male to female ratio of 1.8:1. Majority of the patients had platelet count ranged from 20000/µL to 40000/ µL (44.11%) followed by more than 60000/µL (25%). Patients who were critically ill (12 patients) showed MPV higher when compared to other patients.
Conclusion: Platelet transfusion plays important role in dengue fever yet few patients failed to improve clinically. Though many patients showed improvement in MPV value and total platelet count, few patients did not show much clinical improvement. The underlying causes for failure were bleeding manifestations and immune mediated destruction of platelets. Simply transfusion of platelets to these patients does not make the clinical improvement. Thus identifying the response of platelet transfusion by assessing the MPV value which helps the clinicians to assess the prognosis of patients,
Key words: Dengue fever, Platelets, Mean platelet volume (MPV)[PDF Full Text]