International Journal of Research and Review

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Original Research Article

Year: 2017 | Month: March | Volume: 4 | Issue: 3 | Pages: 42-53

Histological Study on the Protective Effect of Atomoxetine against Olanzapine Induced Weight Gain in Male Albino Rats

Dr. Mohamed Salah Elgendy

Ass. Prof. of Histology, Histology Department, Faculty of Medicine, Fayoum University. Fayoum, Egypt.


Olanzapine is an effective atypical antipsychotic carrying the highest risk of weight gain. Atomoxetine is a Norepinephrine reuptake inhibitor that used mainly in attention deficit hyperactivity disorder in children and was reported to augment Olanzapine effect. Clinical observation showed loss of weight in some patients taking it for other indications. So the aim of this research work is to study the role of Atomoxetine in reducing Olanzapine induced obesity in rats through its effect on adipose tissue structure. We used Forty adult male albino rats which were divided into four groups: control group, Atomoxetine treated group (1 mg/kg/day), Olanzapine treated group (1 mg/kg/day), and group treated with both drugs (co-treated group). Immunohistochemical staining for UCP1 was applied on histological sections. The weight gain in Olanzapine group was significantly reduced when co-treated with Atomoxetine. The size of white adipocytes decreased in co-treated group than Olanzapine group with appearance of UCP1 reactive cells in white adipose tissue and increased immunoreactivity in the brown adipose tissue in rats taking Atomoxetine alone or in co-treated groups. We can conclude that Atomoxetine may be beneficial in decreasing the weight gain induced by Olanzapine through its effect on adipose tissue increasing the activity of brown adipose tissue or browning of white adipose tissue by activating UCP1 in it.

Key words: Olanzapine, Atomoxetine, adipose tissue, UCP1

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