Original Research Article
Year: 2016 | Month: February | Volume: 3 | Issue: 2 | Pages: 45-49
A Case Control Study on the Evaluation of Lipid Profiles as Markers of Depressive Disorders
Prabhakar Singh Bais1, Amitabh Agarwal2, Priyanka Chauhan3
1Asst. Prof. & Head, Dept. of Biochemistry, MLB Medical College, Jhansi-U.P-284128.
2Assistant Professor, Dept of Physiology, Mayo Institute of Medical Sciences, Barabanki, U.P.
3Asso. Prof. & Head, Dept. of Microbiology, K.D. Dental College, Mathura-U.P.
Corresponding Author: Prabhakar Singh Bais
Objective: To evaluate the lipid profiles as markers of depression.
Methods: A total of 65 depressive patients and 65 healthy control subjects were recruited from the department of Psychiatry of a tertiary care hospital. We measured serum total cholesterol (TC), low-density lipoprotein (LDL) and high-density lipoprotein cholesterol and triglyceride levels of both patient and control group.
Results: The serum TC, TG, LDL and VLDL cholesterol levels were found to be significantly lower in case group than that of control group. However, HDL was found to be significantly higher in cases than controls. HDL had high sensitivity as a marker of depression.
Conclusion: The results of this study suggest that the lipid levels could serve as biological markers to distinguish between clinical depressive disorders, however, studies on larger sample size are required for robust conclusion.
Key words: Lipid levels, Depression, Markers.