Original Research Article
Year: 2016 | Month: April | Volume: 3 | Issue: 4 | Pages: 39-45
Thyroid Dysfunction and Possible Role of Anti-TPO in Infertility
Sunita Manhas1*, Shikhaa Mahajan1*, Suvarna Prasad2*, Neeru Bhaskar3*, Pallavi Mahajan4**
1Assistant Professor, 2Professor, 3Professor and Head, 4Demonstrator,
*Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana, India.
**Department of Biochemistry, GMC Jammu, India.
Corresponding Author: Sunita Manhas
Introduction: Thyroid autoimmunity is related to recurrent miscarriages as well as primary and secondary infertility. Infertility and reproductive outcomes can occur if there are abnormalities in both the endocrine and the immune systems by thyroid hormones and thyroid antibodies
Aims And Objectives: 1) To study the association between anti-thyroid peroxidase antibodies and infertility among female patients, 2)To determine the correlation between anti-TPO antibodies, and T3, T4, TSH levels in females with infertility
Material and Method: Cross-Sectional study was done from Jan. 2015 to Dec. 2015. 100 infertile females and 100 age-matched controls were selected. Serum anti-TPO antibodies, T3, T4 and TSH levels were evaluated
Results and Discussion: Out of 100 infertile patients, 39 were of primary and 61 had secondary infertility, out of which anti-TPO Ab was elevated in 55 cases. An increase in the amount of anti-TPO Ab with age was seen. Highly significant increase of TSH and anti-TPO Ab levels was found in cases of primary infertility. Highly significant increase in T4 and anti-TPO Ab levels was seen in secondary infertility. Pearson’s correlations of T3 with T4, T4 with TSH, TSH and anti-TPO Ab with duration of infertility, anti-TPO Ab with infertility were highly significant, T3 with TSH, anti-TPO Ab with T3, TSH with age, T4 and TSH with infertility were significant
Summary and Conclusion: Autoimmunity and thyroid disturbances are related with infertility. Anti-TPO Ab are independently associated with infertility irrespective of thyroid hormones levels and can be used for screening as well as the marker for identifying the risk factor of infertility
Key Words: TPO-Ab, Infertility, Autoimmunity,Thyroid.