International Journal of Research and Review

| Home | Current Issue | Archive | Instructions to Authors | Journals |

Original Research Article

Year: 2016 | Month: March | Volume: 3 | Issue: 3 | Pages: 56-60

An Assessment of the Effect of Sevelamer 800 mg and Calcium Acetate 667 mg with Meals on Biochemical Parameters among the Patients of Non-Diabetic Chronic Kidney Disease: A Non-Randomized Comparative Study

Saurabh Shukla1*, Rajiv Ratan Singh Yadav2*, Arvind Gupta3**, Shiv Shanker Tripathi2*, Sachin Avasthi4*

1Senior Resident, 2Assistant Professor, 3Professor, 4Associate Professor,
*Emergency Medicine, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India.
**Department of Internal Medicine, MLN Medical College, Allahabad.

Corresponding Author: Rajiv Ratan Singh Yadav


Objective: To assess the effect of sevelamer 800 mg and calcium acetate 667 mg with meals on biochemical parameters among the patients of non-diabetic chronic kidney disease.
Methods: This was a prospective comparative study. The diagnosed cases of stable non-diabetic chronic kidney disease coming to the out/in patient clinic were included in the study. The study group was divided into two equal arms; one arm was continued on sevelamer 800 mg with meals (Group 1) and other calcium acetate 667 mg with meals (Group 2) for nine months. All the three levels were subsequently measured again at 6 and 9 months. Hb, TLC, S. urea, creatinine, S. Sodium, Potassium, Serum intact PTH and TSH were measured through standard method.
Results: There was no significant (p>0.05) difference in all the biochemical parameters between the groups at 0 month except for serum intact PTH and TSH. The Hb was significantly decreased in both the groups from 0 month to 9 month. TLC was significantly decreased in Group 1 only from 0 to 6 month (p=0.03) and 9 month (p=0.02) with higher mean change in Group 1 than Group 2. Similar pattern was observed for serum sodium, however, this was increased.  Serum potassium was found to be significantly increased in both the groups from 0 to 9 month.
Conclusion: We found significant effect of both sevelamer and conventional phosphate binder calcium acetate on biochemical parameters.

Key words: Sevelamer, Calcium acetate, Biochemical parameters, chronic kidney disease.

[PDF Full Text]