Year: 2016 | Month: December | Volume: 3 | Issue: 12 | Pages: 1-3
Hepcidin: A review on Potential Mediator between Obesity and Iron Deficiency
Reema Verma1, Alka Gupta2, Ranu Prasad3
1Research Scholar, 2Assistant Professor, 3Professor,
Sam Higginbottom Institute of Agriculture, Technology and Sciences, Allahabad, U.P., India.
Corresponding Author: Reema Verma
Hepcidin is a small peptide hormone secreted by the liver and by adipocytes. Hepcidin is suppressed in iron deficiency, allowing increased absorption of dietary iron and replenishment of iron stores. According to the World Health Organization (WHO) more than 1 billion adults are overweight and at least 300 million of them are obese. Experimental and clinical studies indicate that there is a relationship between iron metabolism and weight status. Iron deficiency is significantly more prevalent among obese individuals compared to non-obese ones. Recently, hepcidin expression in adipose tissue has been described and shown to be increased in patients with severe obesity. The effect of obesity on hepcidin serum levels and treatment outcome of iron deficiency anaemia in children is assessed. Finally, it is conclude that obesity increased hepcidin levels and was associated with diminished response to oral iron therapy in childhood iron deficiency anaemia.
Key words:Hepcidin, Anaemia, Hormone, Overweight, Metabolism.[PDF Full Text]